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Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma
《医学前沿(英文)》 2023年 第17卷 第2期 页码 290-303 doi: 10.1007/s11684-022-0956-8
关键词: benzydamine cyclin-dependent kinase 2 patient-derived xenograft esophageal squamous cell carcinoma
Lentivector-mediated RNAi efficiently downregulates expression of murine cdk4 gene
Feng JIANG PhD , Xuezhen WANG PhD , Zheng XUE MD , Suming ZHANG PhD , Siyu FANG BM , Min ZHANG MD, PhD ,
《医学前沿(英文)》 2009年 第3卷 第3期 页码 287-291 doi: 10.1007/s11684-009-0050-5
关键词: cyclin-dependent kinase 4 RNA interference plasmid lentiviral vector
The role of CDK1 siRNA interference in cell cycle and cell apoptosis
Hui XIAO PhD, Ming TIAN MM, Junna GE MM, Xin Wei MD, Zhaoming LI MM, Xiaolan LI MS, Deding TAO PhD, Junbo HU MD, Jianping GONG MD,
《医学前沿(英文)》 2009年 第3卷 第4期 页码 384-389 doi: 10.1007/s11684-009-0070-1
关键词: cyclin-dependent kinase1 siRNA interference cell cycle apoptosis
Discovery of small molecule degraders for modulating cell cycle
《医学前沿(英文)》 页码 823-854 doi: 10.1007/s11684-023-1027-5
The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases
null
《医学前沿(英文)》 2011年 第5卷 第1期 页码 70-76 doi: 10.1007/s11684-011-0119-9
Protein kinase C epsilon (PKC ?) is one of major isoforms in novel PKC family. Although it has been extensively characterized in the past decade, the role of PKC ? in neuron is still not well understood. Advances in molecular biology have now removed significant barriers to the direct investigation of PKC ? functions in vivo, and PKC ? has been increasingly implicated in the neural biological functions and associated neurogenic diseases. Recent studies have provided important insights into the influence of PKC ? on cortical processing at both the single cell level and network level. These studies provide compelling evidence that PKC ? could regulate distinct aspects of neural signal transduction and suggest that the coordinated actions of a number of molecular signals contribute to the specification and differentiation of PKC ? signal pathway in the developing brain.
关键词: protein kinase C ? signal transduction neurogenic disease
Mechanisms of resistance to third-generation EGFR tyrosine kinase inhibitors
null
《医学前沿(英文)》 2016年 第10卷 第4期 页码 383-388 doi: 10.1007/s11684-016-0488-1
The tyrosine kinase inhibitors (TKI) of the epidermal growth factor receptor (EGFR) are becoming the first line of therapy for advanced non-small cell lung cancer (NSCLC). Acquired mutations in EGFR account for one of the major mechanisms of resistance to the TKIs. Three generations of EGFR TKIs have been used in clinical applications. AZD9291 (osimertinib; Tagrisso) is the first and only FDA approved third-generation EGFR TKI for T790M-positive advanced NSCLC patients. However, resistance to AZD9291 arises after 9–13 months of therapy. The mechanisms of resistance to third-generation inhibitors reported to date include the EGFR C797S mutation, EGFR L718Q mutation, and amplifications of HER-2, MET, or ERBB2. To overcome the acquired resistance to AZD9291, EAI045 was discovered and recently reported to be an allosteric EGFR inhibitor that overcomes T790M- and C797S-mediated resistance. This review summarizes recent investigations on the mechanisms of resistance to the EGFR TKIs, as well as the latest development of EAI045 as a fourth-generation EGFR inhibitor.
Data-driven approach to solve vertical drain under time-dependent loading
《结构与土木工程前沿(英文)》 2021年 第15卷 第3期 页码 696-711 doi: 10.1007/s11709-021-0727-7
关键词: vertical drain artificial neural network time-dependent loading deep learning network genetic algorithm particle swarm optimization
LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing
《医学前沿(英文)》 2008年 第2卷 第3期 页码 235-238 doi: 10.1007/s11684-008-0044-8
关键词: hyperphosphorylation PP2A activity cellular regulation siRNA siRNA transfection
Chloride binding and time-dependent surface chloride content models for fly ash concrete
S. MUTHULINGAM,B. N. RAO
《结构与土木工程前沿(英文)》 2016年 第10卷 第1期 页码 112-120 doi: 10.1007/s11709-015-0322-x
关键词: binding isotherms chloride ingress concrete fly ash surface chloride content
XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing
《医学前沿(英文)》 2007年 第1卷 第2期 页码 200-206 doi: 10.1007/s11684-007-0038-y
《医学前沿(英文)》 2023年 第17卷 第1期 页码 119-131 doi: 10.1007/s11684-022-0949-7
关键词: GDF15 esophageal squamous cell carcinoma chemoresistance cellular metabolism TGFBR2 AKT
null
《医学前沿(英文)》 2012年 第6卷 第4期 页码 411-415 doi: 10.1007/s11684-012-0226-2
Ketamine exerts rapid and robust antidepressant properties in both animal models and depressed patients and tramadol possesses potential antidepressant effects. Brain-derived neurotrophic factor (BDNF) is an important biomarker for mood disorders and tropomyosin-related kinase B (TrkB) is a high affinity catalytic receptor for BDNF. We hypothesized that tramadol pretreatment might reinforce ketamine-elicited antidepressant effects with significant changes in hippocampal BDNF and TrkB levels in rats. Immobility time of rats receiving different treatment in the forced swimming test (FST) was observed. Levels of BDNF and TrkB in hippocampus were measured by enzyme linked immunosorbent assay. Results showed that tramadol (5 mg/kg) administrated alone neither elicited antidepressant effects nor altered BDNF or TrkB level. However, pretreatment with tramadol (5 mg/kg) enhanced the ketamine (10 mg/kg) -elicited antidepressant effects and upregulated the BDNF and TrkB levels in hippocampus. In conclusion, tramadol pretreatment reinforces the ketamine-elicited antidepressant effects, which is associated with the increased levels of BDNF and TrkB in rat hippocampus.
关键词: tramadol ketamine antidepressant brain-derived neurotrophic factor tropomyosin-related kinase B
Pankaj SHARMA,Ajai JAIN
《机械工程前沿(英文)》 2014年 第9卷 第4期 页码 380-389 doi: 10.1007/s11465-014-0315-9
Stochastic dynamic job shop scheduling problem with consideration of sequence-dependent setup times are among the most difficult classes of scheduling problems. This paper assesses the performance of nine dispatching rules in such shop from makespan, mean flow time, maximum flow time, mean tardiness, maximum tardiness, number of tardy jobs, total setups and mean setup time performance measures viewpoint. A discrete event simulation model of a stochastic dynamic job shop manufacturing system is developed for investigation purpose. Nine dispatching rules identified from literature are incorporated in the simulation model. The simulation experiments are conducted under due date tightness factor of 3, shop utilization percentage of 90 % and setup times less than processing times. Results indicate that shortest setup time (SIMSET) rule provides the best performance for mean flow time and number of tardy jobs measures. The job with similar setup and modified earliest due date (JMEDD) rule provides the best performance for makespan, maximum flow time, mean tardiness, maximum tardiness, total setups and mean setup time measures.
关键词: scheduling stochastic dynamic job shop sequence-dependent setup times dispatching rule simulation
null
《医学前沿(英文)》 2015年 第9卷 第2期 页码 134-138 doi: 10.1007/s11684-015-0396-9
Drug resistance is a major factor that limits the efficacy of targeted cancer therapies. In this review, we discuss the main known mechanisms of resistance to receptor tyrosine kinase inhibitors, which are the most prevalent class of targeted therapeutic agent in current clinical use. Here we focus on bypass track resistance, which involves the activation of alternate signaling molecules by tumor cells to bypass inhibition and maintain signaling output, and consider the problems of signaling pathway redundancy and how the activation of different receptor tyrosine kinases translates into intracellular signal transduction in different cancer types. This information is presented in the context of research strategies for the discovery of new targets for pharmacological intervention, with the goal of overcoming resistance in order to improve patient outcomes.
关键词: targeted therapy drug resistance receptor tyrosine kinases cancer
Mitogen-activated protein kinase pathway inhibitors: inhibitors for diseases?
Xu WANG MS, Xiao-Wei GONG MD, PhD, Yong JIANG MD, PhD, Yu-Hua LI PhD,
《医学前沿(英文)》 2010年 第4卷 第1期 页码 46-53 doi: 10.1007/s11684-010-0010-0
关键词: mitogen-activated protein kinase drug target inhibitor signal transduction disease
标题 作者 时间 类型 操作
Repurposed benzydamine targeting CDK2 suppresses the growth of esophageal squamous cell carcinoma
期刊论文
Lentivector-mediated RNAi efficiently downregulates expression of murine cdk4 gene
Feng JIANG PhD , Xuezhen WANG PhD , Zheng XUE MD , Suming ZHANG PhD , Siyu FANG BM , Min ZHANG MD, PhD ,
期刊论文
The role of CDK1 siRNA interference in cell cycle and cell apoptosis
Hui XIAO PhD, Ming TIAN MM, Junna GE MM, Xin Wei MD, Zhaoming LI MM, Xiaolan LI MS, Deding TAO PhD, Junbo HU MD, Jianping GONG MD,
期刊论文
The role of protein kinase C epsilon in neural signal transduction and neurogenic diseases
null
期刊论文
Effect of inhibiting tyrosine kinase Src expression on protein phosphatase 2A and tau phosphorylation
LIU Rong, ZENG Ji, ZHOU Xinwen, WANG Jianzhi, PEI Jinjing
期刊论文
Chloride binding and time-dependent surface chloride content models for fly ash concrete
S. MUTHULINGAM,B. N. RAO
期刊论文
Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventive
XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing
期刊论文
GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal
期刊论文
effects of ketamine with increased levels of brain-derived neurotrophic factor and tropomyosin-related kinase
null
期刊论文
Analysis of dispatching rules in a stochastic dynamic job shop manufacturing system with sequence-dependent
Pankaj SHARMA,Ajai JAIN
期刊论文
Resistance to receptor tyrosine kinase inhibition in cancer: molecular mechanisms and therapeutic strategies
null
期刊论文